Phenethyl bromide → HCID 71503359, compound

HRID 570578Notes

Reaction equation

HRID 570578 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C:21]4[CH:26]=[CH:25]N=[C:23](OC)[CH:22]=4)[CH2:15][CH2:14]3)[S:10][N:9]=2)[CH:5]=[CH:4][N:3]=1.Cl[C:30]1SN=C(C2C=CN=C(Cl)C=2)N=1.BrCCC1C=CC=CC=1>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:30]=[CH:23][CH:22]=4)[CH2:15][CH2:14]3)[S:10][N:9]=2)[CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 7666Phenethyl bromideHCID 71503051HCID 71503051, compoundHCID 86718160HCID 86718160, compound

Product 1

HCID 71503359HCID 71503359, compound

Procedure

In analogy to the procedure described for the synthesis of 3-(2-chloropyridin-4-yl)-5-(4-(2-(2-methoxypyridin-4-yl)ethyl)piperazin-1-yl)-1,2,4-thiadiazole (Example 168), the tile compound was prepared from 5-chloro-3-(2-chloropyridin-4-yl)-1,2,4-thiadiazole and (2-bromoethyl)benzene.

Sources & evidence

ORD record
ord-af70b916c39f4855a604d1b674a8fb6f
Source dataset
uspto-grants-2015_05
Patent number
US09023852B2

Reaction notes

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