Phenethyl bromide → HCID 71187229, compound

HRID 570579Notes

Reaction equation

HRID 570579 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][N:16](CCC4C=CN=C(OC)C=4)[CH2:15][CH2:14]3)[S:10][N:9]=2)[CH:5]=[CH:4][N:3]=1.Cl[C:30]1SN=C(C2C=CN=C(Cl)C=2)N=1.Br[CH2:43][CH2:44][C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1>>[CH3:30][C:2]1[CH:7]=[C:6]([C:8]2[N:12]=[C:11]([N:13]3[CH2:14][CH2:15][N:16]([CH2:43][CH2:44][C:45]4[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=4)[CH2:17][CH2:18]3)[S:10][N:9]=2)[CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 7666Phenethyl bromideHCID 71503051HCID 71503051, compoundHCID 86718160HCID 86718160, compound

Product 1

HCID 71187229HCID 71187229, compound

Procedure

In analogy to the procedure described for the synthesis of 3-(2-chloropyridin-4-yl)-5-(4-(2-(2-methoxypyridin-4-yl)ethyl)piperazin-1-yl)-1,2,4-thiadiazole (Example 168), the tile compound was prepared from 5-chloro-3-(2-chloropyridin-4-yl)-1,2,4-thiadiazole and (2-bromo ethyl)benzene.

Sources & evidence

ORD record
ord-a35273c3b5f94af2a0cc45366ce2c20f
Source dataset
uspto-grants-2015_05
Patent number
US09023852B2

Reaction notes

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