HCID 71503051, compound → HCID 71186542, compound

HRID 570580Notes

Reaction equation

HRID 570580 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C:21]4[CH:26]=[CH:25][N:24]=[C:23]([O:27][CH3:28])[CH:22]=4)[CH2:15][CH2:14]3)[S:10][N:9]=2)[CH:5]=[CH:4][N:3]=1.Cl[C:30]1SN=C(C2C=CN=C(Cl)C=2)N=1.Cl.Cl.Cl.COC1C=C(CCN2CCNCC2)C=CN=1>>[CH3:28][O:27][C:23]1[CH:22]=[C:21]([CH2:20][CH2:19][N:16]2[CH2:17][CH2:18][N:13]([C:11]3[S:10][N:9]=[C:8]([C:6]4[CH:5]=[CH:4][N:3]=[C:2]([CH3:30])[CH:7]=4)[N:12]=3)[CH2:14][CH2:15]2)[CH:26]=[CH:25][N:24]=1

Participants

4

Reactant 3

HCID 71503051HCID 71503051, compoundHCID 86718160HCID 86718160, compoundHCID 86718161HCID 86718161, compound

Product 1

HCID 71186542HCID 71186542, compound

Procedure

In analogy to the procedure described for the synthesis of 3-(2-chloropyridin-4-yl)-5-(4-(2-(2-methoxypyridin-4-yl)ethyl)piperazin-1-yl)-1,2,4-thiadiazole (Example 168), the tile compound was prepared from 5-chloro-3-(2-chloropyridin-4-yl)-1,2,4-thiadiazole and 1-(2-(2-methoxypyridin-4-yl)ethyl)piperazine trihydrochloride.

Sources & evidence

ORD record
ord-e6c5196a59f44bc3bbcdb0759981283c
Source dataset
uspto-grants-2015_05
Patent number
US09023852B2

Reaction notes

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