反应详情

温度

120 °C

To a solution of (8-chloro-[1,2,4]triazolo[1,5-a]pyrazine-2-yl]-(3,5-dimethoxy-phenyl)-amine (0.2 g, 0.65 mmol, 1 eq) in a mixture of dimethoxy ethane (3 ml) and water (1 ml), 3-aminomethylphenyl boronic acid (0.28 g, 1.31 mmol, 2 eq), sodium carbonate (0.14 g, 1.31 mmol, 2 eq)) and dichlorobis(triphenyl-phospine)palladium (II) (0.023 g, 0.03 mmol, 5%) are taken in a microwave vial and heated at 120° C. for 2 hours. The reaction mixture is concentrated and the residue is taken in dichloromethane (10 ml×1), washed with brine solution (10 ml×1), the organic layer is dried over anhydrous MgSO4 and concentrated. The crude product obtained is purified by silica gel column using (230-400) mesh to get the titled product as yellow solid.

1. concentrationThe reaction mixture is concentrated
2. washwashed with brine solution (10 ml×1)
3. dry with materialthe organic layer is dried over anhydrous MgSO4
4. concentrationconcentrated
5. customThe crude product obtained
6. customis purified by silica gel column