Sodium Carbonate → HCID 56847069, compound

Participants

Reaction Conditions

Reaction Steps

8-Chloro-N-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrazin-2-amine (100 mg, 0.319 mmol), 2-thiazolyl zinc bromide (0.5 M in THF, 5 mL, 0.478 mmol), sodium carbonate (2M) (0.24 mL, 0.5 mmol) and tetrakis(triphenyl phosphine) palladium (11 mg, 0.05 mmol) are dissolved and degassed in a mixture of toluene:ethanol (1:1, 4 mL). The reaction mixture is heated 4 hours at 90° C. in a sealed tube. When the reaction is completed, the reaction mixture is cooled down to rt and filtrated through a celite pad and washed with ethyl acetate (10 mL). The filtrate is concentrated and purified by flash chromatography on a silica gel column using (60-120) mesh to get the product as a yellow solid (6.6 mg, 6%); LCMS (method A): mass found (M+H+, 363), Rt (min): 4.50 area % 95.5 (max), 93.5 (254 nm).

Provenance & Evidence