Thiophosgene → 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile

Participants

Reaction Steps

Thiophosgene (10 g, 87.71 mmol) was dissolved in water and stirred at RT for 10 min. 4-Amino-2-trifluoromethyl-benzonitrile was added portionwise at RT. The reaction mixture was stirred at RT for 2 h. The product was extracted with DCM, the organic layer was washed with water and brine, dried over sodium sulphate and evaporated to obtain 12 g of 4-isothiocyanato-2-trifluoromethyl-benzonitrile.

Provenance & Evidence