Methyl iodide → HCID 86645397, compound

Participants

Reaction Steps

A solution of propyl (4-fluoro-7-oxo-6,7,8,9-tetrahydropyrido[1,2-α]indol-10-yl)acetate in THF (0.17 M) was treated at −78° C. with a 1.0 M solution of NaHMDS in THF (1.2 eq.). After stirring for 10 min, MeI (2.0 eq.) was added. The cooling bath was removed and the mixture stirred for 1 hour, concentrated to dryness and the residue purified by chromatography on SiO2 (0-100% EtOAc/hexanes).

Provenance & Evidence