HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-Fluoro-4-(2-methylbut-3-yn-2-yl)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(4-Fluorophenyl)-2-methylpropanal | HCID 82074750 | — |
| Reactant | (1E)-1-diazo-1-dimethoxyphosphorylpropan-2-one | HCID 136023029 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-Fluoro-4-(2-methylbut-3-yn-2-yl)benzene | HCID 19825872 | — |
Reaction Steps
Next, a solution of dimethyl (1-diazo-2-oxopropyl)phosphonate (1.4 eq.) in MeOH (0.6 M) was treated at 0° C. with K2CO3 (2.4 eq.) and 2-(4-fluorophenyl)-2-methylpropanal (1.0 eq.). The reaction mixture was stirred for 1 hour, diluted with EtOAc, washed with water, dried (Na2SO4) and concentrated giving 1-fluoro-4-(2-methylbut-3-yn-2-yl)benzene: 1H NMR (600 MHz, CDCl3) δ 7.48-7.50 (m, 2 H), 6.97-7.00 (m, 2 H), 2.33 (s, 1 H), 1.57 (s, 6 H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09023864B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-beca74a66ecb4b9f8befce913a8e3ddd |
| Source note | uspto-grants-2015_05 |