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HRID57068

反应详情

EQUATION

反应方程式

HRID 57068 的结构方程式

REACTANTS

反应物

2
结构：CCC(C(=O)O)n1cc(OC)c(-c2cc(Cl)ccc2C#N)cc1=O
HCID117622569

未命名化合物

结构：Nc1ccc(-c2nsc(=O)[nH]2)cc1
HCID136930237

未命名化合物

PRODUCTS

生成物

1
结构：CCC(C(=O)Nc1ccc(-c2nsc(=O)[nH]2)cc1)n1cc(OC)c(-c2cc(Cl)ccc2C#N)cc1=O
HCID136930242

未命名化合物

PROCEDURE

实验过程

65 mg (0.19 mmol) of 2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]butanoic acid (racemate) and 54 mg (0.28 mmol, 1.5 eq.) of 3-(4-aminophenyl)-1,2,4-thiadiazol-5(4H)-one were reacted according to General Method 7. The crude product was purified by preparative HPLC (water/acetonitrile/0.1% formic acid gradient). Yield: 45 mg (46% of theory)

WORKUP

后处理

  1. customThe crude product was purified by preparative HPLC (water/acetonitrile/0.1% formic acid gradient)