HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → ethyl (2E)-3-amino-3-[bis(2,4-dimethoxybenzyl)amino]prop-2-enoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Propanoic acid, 3-ethoxy-3-imino-, ethyl ester | HCID 75346 | — |
| Reactant | Bis(2,4-dimethoxybenzyl)amine | HCID 88696 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | ethyl (2E)-3-amino-3-[bis(2,4-dimethoxybenzyl)amino]prop-2-enoate | HCID 86685371 | 156.7% |
Reaction Steps
A mixture of bis(2,4-dimethoxybenzyl)amine (8 g), ethyl 3-ethoxy-3-iminopropanoate (8.02 g), acetic acid (1.44 mL) and ethanol (420 mL) was refluxed overnight. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (17 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09023858B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-25f6f8b84c8e48d2bbfce6c8e618e59a |
| Source note | uspto-grants-2015_05 |