反应详情

温度

100 °C

7-(2,4-Dimethoxybenzyl)-2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,5,6,7-tetrahydropyrido[3,4-d]pyrimidine-4,8-dione (71 mg) was dissolved in formic acid (3 ml), and the solution was stirred at 100° C. for 1 hr, allowed to be cooled to room temperature, and concentrated under reduced pressure. The residue was subjected to azeotropic distillation with toluene. The obtained white solid was purified by silica gel column chromatography (methanol/ethyl acetate) to give the title compound (38 mg) as a white solid.

1. temperatureto be cooled to room temperature
2. concentrationconcentrated under reduced pressure
3. distillationThe residue was subjected to azeotropic distillation with toluene
4. customThe obtained white solid was purified by silica gel column chromatography (methanol/ethyl acetate)