HCID 86685391, compound → HCID 68015322, compound

Participants

Reaction Conditions

Reaction Steps

7-(2,4-Dimethoxybenzyl)-2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,7-dihydropyrido[3,4-d]pyrimidine-4,8-dione (219 mg) was dissolved in formic acid (5 ml), and the solution was stirred at 100° C. for 3 hr, allowed to be cooled to room temperature, and concentrated under reduced pressure. To the residue was added toluene, and the mixture was again concentrated under reduced pressure. The residue was purified by silica gel column chromatography (NH, methanol/ethyl acetate), and recrystallized from a mixed solvent of ethyl acetate/hexane/methanol to give the title compound (132 mg).

Provenance & Evidence