2,2,2-Trifluoroethanol → HCID 86685392, compound

Participants

Reaction Steps

To a solution of 2,2,2-trifluoroethanol (0.052 ml) in N,N-dimethylformamide (3 ml) was added sodium hydride (60% in oil, 24 mg) at room temperature, and the mixture was stirred for 5 min. A solution of 2-(propylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,7-dihydropyrido[3,4-d]pyrimidine-4,8-dione (535 mg) in N,N-dimethylformamide (3 ml) was added to the reaction mixture, and the mixture was stirred at 60° C. for 4 hr. The reaction mixture was allowed to be cooled to room temperature, saturated brine was added thereto, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, methanol/ethyl acetate), and recrystallized from a mixed solvent of ethyl acetate/hexane to give the title compound (8 mg).

Provenance & Evidence