Phosphorus oxychloride → HCID 86685394, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-ethoxy-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,7-dihydropyrido[3,4-d]pyrimidine-4,8-dione (763 mg) and phosphorus oxychloride (10 ml) was stirred at 100° C. for 5 hr, allowed to be cooled to room temperature, and concentrated under reduced pressure. To the residue was added toluene, and the mixture was again concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (437 mg).

Provenance & Evidence