Cesium carbonate → HCID 86685402, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of palladium(II) acetate (49.0 mg) and 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (189 mg) in toluene (20 mL) were added 6-oxo-2-propyl-1-[4-(2,2,2-trifluoroethoxy)phenyl]-1,6-dihydropyrimidin-4-yl trifluoromethanesulfonate (1.0 g), 4-methoxybenzylamine (0.43 mL) and cesium carbonate (1.77 g) at room temperature, and the mixture was stirred at 100° C. for 3 hr. To the reaction mixture were added ethyl acetate and water, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to aminopropylsilane-bonded silica gel column chromatography (ethyl acetate/hexane) to give the title compound (462 mg) as a solid.

Provenance & Evidence