Hydrogen chloride-ethyl acetate → HCID 86685409, compound

HRID 570752Notes

Reaction equation

HRID 570752 reaction equation
C(OC(=O)C)C.[ClH:7].[O:8]=[C:9]1[N:14]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]([F:26])([F:25])[F:24])=[CH:17][CH:16]=2)[C:13]([S:27][CH2:28][CH2:29][NH:30]C(=O)OC(C)(C)C)=[N:12][C:11]2=[CH:38][S:39][CH:40]=[C:10]12>CO>[ClH:7].[NH2:30][CH2:29][CH2:28][S:27][C:13]1[N:14]([C:15]2[CH:16]=[CH:17][C:18]([O:21][CH2:22][C:23]([F:24])([F:26])[F:25])=[CH:19][CH:20]=2)[C:9](=[O:8])[C:10]2[C:11](=[CH:38][S:39][CH:40]=2)[N:12]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86685408HCID 86685408, compound

Product 1

HCID 86685409HCID 86685409, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixed solution of 4N hydrogen chloride ethyl acetate solution (20 ml) and methanol (10 ml) was added tert-butyl [2-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,4-dihydrothieno[3,4-d]pyrimidin-2-yl}sulfanyl)ethyl]carbamate (1.7 g), and the mixture was stirred at room temperature for 14 hr. The reaction mixture was concentrated under reduced pressure, and the residue was washed with a mixture of ethyl acetate/ether (1/1) to give the title compound (1.48 g) as a white solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. washthe residue was washed with a mixture of ethyl acetate/ether (1/1)

Sources & evidence

ORD record
ord-82740fcf569e4c6192a1382e240d37e0
Source dataset
uspto-grants-2015_05
Patent number
US09023858B2

Reaction notes

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