m-Chloroperbenzoic acid → HCID 89488469, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-[3-[[2,6-dibromo-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]-methyl-carbamoyl]-2-methoxy-phenyl]-N-methyl-pyridine-4-carboxamide (Example G-17) (0.0657 g, 0.178 mmole) in dichloromethane (1.08 ml) was added by small portions 3-chloroperbenzoic acid (purity 70%) (0.0657 g, 0.266 mmole). After 2.5 hours stirring at 25° C., the yellow solution was quenched with aqueous sodium sulfite, diluted with dichloromethane and washed twice with saturated aqueous sodium bicarbonate, then with brine. The organic solution was dried over sodium sulfate. The product was isolated after removal of the solvent, as a white powder (melting range: 134-230° C.) showing, by LC-MS analysis (method 6 described hereunder) a retention time of 1.03 min and a M+H+ peak of 702.

Provenance & Evidence