3-Chloro-4-hydroxybenzaldehyde → Benzonitrile, 3-chloro-4-hydroxy-

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Reaction Steps

The title compound was prepared from 3-chloro-4-hydroxybenzaldehyde and hydroxyl ammonium chloride, using the same method as that described for preparation 70. The title compound was purified by column chromatography on silica gel, eluting with pentane:ethyl acetate, 100:0 to 90:10, to afford the title compound as a white solid in 76% yield.

Provenance & Evidence