反应详情

To a solution of 4-phenyl-1H-pyrrole-3-carbonitrile (0.168 g), cupper (I) iodide (0.019 g), N,N-dimethyl grycine (0.021 g) and cesium carbonate (0.325 g) in dimethylsulfoxide (10 mL) was added 2-chloro-4-iodopyridine (0.287 g) at room temperature, and this mixture was at 180° C. in a sealed tube under microwave irradiation for 5 minutes. After cooling to ambient temperature, this reaction mixture was diluted with dichloromethane and water, and the insoluble material was removed by filtered though a Celite pad. This organic layer was separated and this organic solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: ethyl acetate/hexane=80/20) to give the title compound (0.16 g).

1. customthis mixture was at 180° C. in a sealed tube under microwave irradiation for 5 minutes
2. customthe insoluble material was removed
3. filtrationby filtered though a Celite pad
4. customThis organic layer was separated
5. customthis organic solvent was removed under reduced pressure
6. customThe residue was purified by column chromatography on silica gel (eluent: ethyl acetate/hexane=80/20)