Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | HCID 59224848 | HCID 59224848 | — |
| Reactant | 4-[2-(Benzyloxy)phenyl]-1H-pyrrole-3-carbonitrile | HCID 59478030 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59477635 | HCID 59477635 | 87.2% |
Reaction Steps
To a solution of 4-(2-benzyloxyphenyl)-1H-pyrrole-3-carbonitrile (1.5 g), 4-fluoro-2-methoxymethoxybenzoic acid ethyl ester (1.4 g) in N,N-dimethylformamide (25 mL) was added cesium carbonate, and this mixture was stirred at 65° C. for 15 hours. This reaction mixture was poured into water, the precipitated solid was collected by filtration, and washed with water and n-hexane, dried under reduced pressure at 50° C. to give the title compound (2.3 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09023882B2 |
|---|
| Source dataset | uspto-grants-2015_05 |
|---|
| ORD ID | ord-19f622d774264fc1bd78be960be255f5 |
|---|
| Source note | uspto-grants-2015_05 |
|---|
