Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Silicon tetrachloride | HCID 24816 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 4-Pyridinecarboxamide, 2-(3-cyano-4-phenyl-1H-pyrrol-1-yl)- | HCID 68508763 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178510289 | HCID 178510289 | 80.9% |
Reaction Steps
To a solution of 2-(3-cyano-4-phenylpyrrole-1-yl)isonicotinamide (0.058 g) and sodium azide (0.039 g) in a mixed solvent of acetonitrile (1.0 mL) and tetrahydrofuran (0.5 mL) was added tetrachlorosilane (0.068 g) at room temperature, and this mixture was stirred at 80° C. overnight. To this reaction mixture was added water, this obtained solid was collected by filtration. After washing with water, this solid was dried at 50° C. under reduced pressure to give the title compound (0.051 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09023882B2 |
|---|
| Source dataset | uspto-grants-2015_05 |
|---|
| ORD ID | ord-85d35ba51b7e4902ae7ef92a74a92554 |
|---|
| Source note | uspto-grants-2015_05 |
|---|
