Biotin → HCID 86643046, compound

Participants

Reaction Conditions

Reaction Steps

54.1 g of ascorbic acid (306.9 mmol; 5 eq.) and 15 g of biotin (61.4 mmol; 1 eq.) are dissolved in 180 ml of anhydrous acetone under a protective gas, 1 g of lipase (Candida antarctica) is added, and the mixture is shaken at 40° C. for 32 h. The enzyme is filtered off, 50 ml of water are added to the solution, and the product is precipitated by pouring into toluene.

Provenance & Evidence