1-Bromo-3-methanesulfonylpropane → [3-(3-Bromo-propane-1-sulfonyl)-propoxy]-tert-butyl-dimethyl-silane

HRID 570877Notes

Reaction equation

HRID 570877 reaction equation
[C:1]([Si:5]([CH3:18])([CH3:17])[O:6][CH2:7][CH2:8][CH2:9][S:10]([CH2:13][CH2:14][CH2:15]O)(=[O:12])=[O:11])([CH3:4])([CH3:3])[CH3:2].[Br:19]CCCS(C)(=O)=O>>[Br:19][CH2:15][CH2:14][CH2:13][S:10]([CH2:9][CH2:8][CH2:7][O:6][Si:5]([C:1]([CH3:4])([CH3:3])[CH3:2])([CH3:18])[CH3:17])(=[O:12])=[O:11]

Participants

3

Reactant 2

HCID 518920821-Bromo-3-methanesulfonylpropaneHCID 866782233-[3-(tert-Butyl-dimethyl-silanyloxy)-propane-1-sulfonyl]-propan-1-ol

Product 1

HCID 86678222[3-(3-Bromo-propane-1-sulfonyl)-propoxy]-tert-butyl-dimethyl-silane

Procedure

Intermediate 24 (485 mg) was prepared from Intermediate 20 (1.18 g, 4 mmol)) according to an analogous procedure to that described for Intermediate 14.

Sources & evidence

ORD record
ord-24774420c4854dbab3e85d331bd4afca
Source dataset
uspto-grants-2015_05
Patent number
US09023855B2

Reaction notes

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