Tetrabutylammonium Fluoride → HCID 71293508, compound

Participants

Reaction Steps

Intermediate 27 (620 mg, 0.85 mmol) was dissolved in THF (7 mL), and then a solution of 1 M TBAF in THF (1.3 ml, 1.3 mmol) was added. The reaction mixture was stirred at RT for 16 hours and then partitioned between EtOAc and water. The organic layer was separated, and the aqueous layer further extracted with EtOAc. The combined organic layers were washed with brine, dried (Na2SO4) and evaporated in vacuo. The resulting residue was purified by silica gel chromatography eluting with a gradient of 4-5% methanol in DCM to afford the title compound as a colourless oil (476 mg).

Provenance & Evidence