Tetrahydrofuran → HCID 86678224, compound

Participants

Reaction Steps

Intermediate 28 (470 mg, 0.76 mmol) was dissolved in THF (5 ml), and then sodium hydride (48 mg, 1.2 mmol) was added under an atmosphere of N2. The reaction mixture was stirred at RT for 10 mins, then toluenesulfonyl chloride (191 mg, 1 mmol) was added and stirring was continued for 16 hours. The reaction mixture was partitioned between EtOAc and water. The organic layer was separated, washed with brine, dried (Na2SO4) and evaporated in vacuo. The resulting residue was purified by silica gel chromatography Bluing with a gradient of 50-80% EtOAc in cyclohexane to give the title compound as a pale yellow glass (132 mg).

Provenance & Evidence