HCID 86678225, compound → HCID 71509868, compound

HRID 570888Notes

Reaction equation

HRID 570888 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]([C:11]2[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[CH:13][CH:12]=2)[N:9]2[C:19](=[O:31])[N:20]([CH2:22][C:23]3[CH:28]=[CH:27][C:26]([CH2:29][Br:30])=[CH:25][CH:24]=3)[N:21]=[C:8]2[N:7]([C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([C:38]([F:41])([F:40])[F:39])[CH:33]=2)[C:6]=1[CH3:42])=[O:4]>CN(C)C.C(O)C>[Br-:30].[C:17]([C:14]1[CH:15]=[CH:16][C:11]([CH:10]2[N:9]3[C:19](=[O:31])[N:20]([CH2:22][C:23]4[CH:24]=[CH:25][C:26]([CH2:29][N+:7]([CH3:32])([CH3:8])[CH3:6])=[CH:27][CH:28]=4)[N:21]=[C:8]3[N:7]([C:32]3[CH:37]=[CH:36][CH:35]=[C:34]([C:38]([F:40])([F:39])[F:41])[CH:33]=3)[C:6]([CH3:42])=[C:5]2[C:3]([O:2][CH3:1])=[O:4])=[CH:12][CH:13]=1)#[N:18]

Participants

4

Reactant 1

HCID 86678225HCID 86678225, compound

Product 1

HCID 71509868HCID 71509868, compoundYield 111.1%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 1146TrimethylamineSolvent

Procedure

Intermediate 15 (105 mg, 0.16 mmol) was dissolved in a solution of 31% trimethylamine in ethanol. The reaction mixture was stirred at RT for 16 hours and then filtered. The solid was collected by filtration and dried in vacuo to yield the title compound as a white solid (62 mg).

Workup

  1. filtrationfiltered
  2. filtrationThe solid was collected by filtration
  3. customdried in vacuo

Sources & evidence

ORD record
ord-a933f2b634b44b1fb2fa1e37ff01af5e
Source dataset
uspto-grants-2015_05
Patent number
US09023855B2

Reaction notes

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