Trifluoroacetic acid → HCID 71293414, compound

Participants

Reaction Steps

To a solution of Intermediate 18 (0.12 g, 0.19 mmol) in DCM (2.5 mL), was added TFA (0.25 mL). The resulting mixture was stirred at RT for 1 hour, and then evaporated in vacuo. The resulting residue was taken up in DCM (4 mL), and triethylamine (86 μL, 0.62 mmol) was added, followed by acetic anhydride (47 μL, 0.50 mmol). The reaction mixture was stirred at RT for 30 mins and was then partitioned between EtOAc and water. The organic layer was separated, and the aqueous layer further extracted with EtOAc. The combined organic layers were washed with brine, dried (Na2SO4) and evaporated in vacuo. The resulting residue was purified by silica gel chromatography eluting with a gradient 0-10% MeOH in DCM to yield the title compound as a white solid (80 mg).

Provenance & Evidence