HCID 89601667, compound → HCID 89601660, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of tert-butyl 4-[acetyl(tert-butoxycarbonyl)amino]-6-(benzyloxymethyl)-3-oxo-5H-1,2,4-triazine-2-carboxylate (38.0 g, 79.7 mmol) in EtOH (400 mL) under argon atmosphere was added palladium on charcoal (dry, 5 wt % Pd, 8.00 g). The reaction mixture was purged with hydrogen and heated to 60° C. At this temperature, the reaction mixture was stirred 24 h under H2-atmosphere (approx. 1 atm). The mixture was purged with argon and then filtered using a short plug of silica gel followed by rinsing with additional EtOAc. Evaporation of the solvent furnished the desired product as a sticky oil. LCMS (Method I) RT 1.57 min. [M+H]+ 387.

Provenance & Evidence