HCID 89601756, compound → HCID 89602037, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-[acetyl(tert-butoxycarbonyl)amino]-6-formyl-3-oxo-5H-1,2,4-triazine-2-carboxylate (1.15 g, 3.00 mmol) [prepared according to Example 1, Step F] in THF (11.0 mL) at 0° C. was slowly added MeMgBr (3M solution in Et2O, 1.50 mL, 4.50 mmol) via syringe. The reaction mixture was allowed to warm to room temperature and stirred for another 20 h. The reaction mixture was quenched with sat NH4Cl solution and the aqueous layer extracted EtOAc. After washing of the combined organic layers with brine and drying (Na2SO4), the solvent was removed in vacuo to give the desired product as a viscous oil. LCMS (Method I) RT 1.19 min. [M+Na]+ 323.

Provenance & Evidence