O-ethylhydroxylamine hydrochloride → HCID 89601426, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 4-[acetyl(tert-butoxycarbonyl)amino]-6-formyl-3-oxo-5H-1,2,4-triazine-2-carboxylate (192 mg, 0.500 mmol) and sodium acetate (45 mg, 0.55 mmol) in EtOH (1.0 mL) at room temperature was added O-ethylhydroxylamine HCl-salt (54 mg, 0.55 mmol). The mixture was heated to 70° C. and stirred for 2 h. The obtained reaction mixture was filtered hot and the solid residual washed with EtOH. The filtrate was concentrated to give the desired product which was used without further purification. LCMS (Method I) RT 1.94 min. [M+Na]+ 450.

Provenance & Evidence