反应详情

To a solution of 3-bromopyruvic acid (1.388 g; 8.3 mmol) in dry acetonitrile (20 mL) was added 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbothioamide (1.000 g; 4.8 mmol). The mixture was stirred at room temperature overnight, and then concentrated under reduced pressure. The residue was washed with DCM (3×15 mL) and diethyl ether (2×20 mL) and the pale yellow solid (1.20 g; 84%) was used without further purification.

1. concentrationconcentrated under reduced pressure
2. washThe residue was washed with DCM (3×15 mL) and diethyl ether (2×20 mL)
3. customthe pale yellow solid (1.20 g; 84%) was used without further purification