Methyl N-(triethylammoniosulfonyl)carbamate → HCID 66831858, compound

Participants

Reaction Steps

N′-benzoyl-3-(methylthiomethyl)-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbohydrazide (0.47 mmol, 170 mg, 1 eq.) and 1-methoxy-N-triethylammoniosulfonyl-methanimidate (Burgess Reagent) (1.61 mmol, 383 mg, 3.4 eq.) were dissolved in THF (8 mL). Microwave energy was applied to the solution for 5 minutes, keeping reaction temperature at 60° C. The reaction mixture was poured into ice/water and the formed solid was filtered and washed with water, acetonitrile and ether, and dried under vacuum to give the title compound. Yield 71%. δH (DMSO-d6) 8.90 (1H, bs), 7.92 (2H, bs), 7.49 (3H, bs), 5.29 (2H, bs), 2.09 (3H, bs).

Provenance & Evidence