Methyl iodide → Methyl 4-oxo-3-(prop-2-ynyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbimidothioate hydroiodide

HRID 570941Notes

Reaction equation

HRID 570941 reaction equation
[O:1]=[C:2]1[N:7]([CH2:8][C:9]#[CH:10])[N:6]=[N:5][C:4]2=[C:11]([C:14](=[S:16])[NH2:15])[N:12]=[CH:13][N:3]12.[I:17][CH3:18]>CC#N>[IH:17].[CH3:18][S:16][C:14]([C:11]1[N:12]=[CH:13][N:3]2[C:2](=[O:1])[N:7]([CH2:8][C:9]#[CH:10])[N:6]=[N:5][C:4]=12)=[NH:15]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 498691414-Oxo-3-(prop-2-ynyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbothioamide

Product 1

HCID 86663789Methyl 4-oxo-3-(prop-2-ynyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbimidothioate hydroiodide

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

4-oxo-3-(prop-2-ynyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbothioamide (0.323 g; 0.86 mmol) was dissolved in dry MeCN (1 mL) and iodomethane (1.220 g; 8.6 mmol) was added and the reaction mixture stirred at room temperature overnight.

Sources & evidence

ORD record
ord-c9eedfe3fe944eee8221b6d9f5b6b56a
Source dataset
uspto-grants-2015_05
Patent number
US09024018B2

Reaction notes

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