Potassium hydroxy sulfite → HCID 49869006, compound

Participants

Reaction Steps

An aqueous solution (250 μL) of Oxone™ (54 mg, 0.195 mmol) was added to a stirred solution of 8-(benzo[d]oxazol-2-yl)-3-(methylthiomethyl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one (25 mg, 0.0795 mmol) in DMF (1 mL) and the resulting suspension was stirred overnight. The mixture was poured into ice (10 g) and the precipitate was filtered and washed successively with water, ethyl acetate and diethyl ether to give 19 mg of the title compound as a bright yellow solid (73% yield). δH (DMSO d6): 9.12 (1H, s), 7.89-7.94 (2H, m), 7.47-7.55 (2H, m), 5.66 (1H, d, J=13.2), 5.53 (1H, d, J=13.2), 2.80 (3H, s). LCMS: 97% pure at 4.63 min., m/z (ES+): 331.1 (MH+).

Provenance & Evidence