N-(2-aminophenyl)-3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide → HCID 135985849, compound

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A solution of N-(2-aminophenyl)-3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide (300 mg) in 3N HCl (15 mL) was heated at 90° C. overnight. After cooling to room temperature, the mixture was concentrated to dryness under high vacuum and the residue was dissolved in MeCN:MeOH. Triethylamine (170 μL) was added to the solution and the crude product was absorbed on silica and purified by flash chromatography using DCM:MeOH (95:5) as eluent to give 8 mg of the pure title compound as a green solid (3% yield). δH (DMSO d6): 13.0 (1H, s), 8.99 (1H, s), 7.73-7.75 (1H, d, J=7.5), 7.56-7.58 (1H, d, J=7.5), 7.23-7.27 (2H, m), 3.90 (3H, s).

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