HCID 136340694, compound → HCID 178509098, compound

Participants

Reaction Steps

5% Palladium on carbon (0.5 g) was added to a solution of (E)-5-nitro-4-(2-(thiophen-2-yl)vinyl)-1H-imidazole (4.5 g, 0.02 mol) in methanol (500 mL) and the resulting mixture hydrogenated at atmospheric pressure for 24 hours. The catalyst was removed by filtering through a short bed of Celite™, and the Celite™ washed with 10% MeOH/DCM (200 mL). The filtrate was evaporated to dryness and purified by column chromatography (5-10% MeOH/DCM) to leave the product as a pale brown solid (2.75 g, 71%). δH (DMSO-d6) 11.58 (1H, bs, NH), 7.25 (2H, m), 6.95 (3H, m), 6.62 (1H, d, J=16.0), 4.86 (2H, bs, NH2).

Provenance & Evidence