Lawesson's reagent → HCID 178425914, compound

Participants

Reaction Steps

A mixture of 4-methyl-3-[(quinolin-3-yl)ethynyl]benzoic acid (0.3 g, 1.3 mmol) and Lawesson's reagent (0.5 ml, 1.3 mmol) in THF (10 ml) was stirred at ambient temperature for 1 hr under an atmosphere of nitrogen. The reaction mixture was concentrated and the crude product was purified by flash chromatography on silica gel (elution with 10% ethyl acetate in n-hexane) to provide 4-methyl-3-[(quinolin-3-yl)ethynyl]thiobenzoic acid.

Provenance & Evidence