1-Hydroxybenzotriazole → HCID 59053813, compound

Participants

Reaction Steps

A mixture of 6-[(quinolin-3-yl)ethynyl]pyridine-2-carboxylic acid (0.05 g, 0.2 mmol), N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (0.04 g, 0.2 mmol) and 1-hydroxybenzotriazole (0.03 g, 0.2 mmol) in N,N-dimethylformamide (10 ml) was stirred at ambient temperature for 1 hr. 2-chloro-6-methylbenzohydrazide (0.03 g, 0.2 mmol) was added and the mixture stirred for 12 hrs at ambient temperature. Concentration and trituration of the residue with water produced a solid which was filtered, washed with water and dried in vacuo. Leaching the product with methanol and drying in vacuo gave N′-(2-Chloro-6-methylbenzoyl)-6-[2-(3-quinolyl)ethynyl]pyridine-2-carboxylic acid hydrazide as a white solid.

Provenance & Evidence