HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → benzylguanine N-Fmoc-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}piperidine-4-carboxylic acid | HCID 2736490 | — |
| Reactant | 6-Aminomethylbenzylguanine | HCID 136386261 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | benzylguanine N-Fmoc-piperidine | HCID 136386262 | — |
Reaction Steps
Weighed into a 50 ml round-bottomed flask were 48.1 mg (178 μmol) of 6-aminomethylbenzylguanine which was partially dissolved in 10 ml of anhydrous dimethylformamide. 62.5 mg (178 μmol) of 4-carboxy-N-Fmoc-piperidine and 57.1 mg (178 μmol) of TBTU were added. The reaction mixture was left stirring for two hours. The reaction was monitored by HPLC on a Merck Lichrospher RP °18, 5 μm, 125×4.6 column with a gradient of acetonitrile in water containing 0.2% of trifluoroacetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09024022B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-bceedb4d589c41efb05e7185ba13d1b3 |
| Source note | uspto-grants-2015_05 |