関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2,6-Dibromopyridine | HCID 12274 | — |
| 反応物 | 3-[(4-Methoxyphenyl)methoxy]-4(1H)-pyridinone | HCID 67405695 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 6'-bromo-3-[(4-methoxybenzyl)oxy]-4H-1,2'-bipyridin-4-one | HCID 86680274 | — |
反応手順
A mixture of 3-[(4-methoxybenzyl)oxy]pyridin-4(1H)-one (2.31 g, 10 mmol), 2,6-dibromopyridine (4.74 g, 20 mmol), and K2CO3 (3.45 g, 25 mmol) in DMSO was heated at 120° C. overnight. After cooling to rt, the solid was removed by filtration and the DMSO solution was purified by flash chromatography to give 6′-bromo-3-[(4-methoxybenzyl)oxy]-4H-1,2′-bipyridin-4-one. 1H NMR (600 MHz, DMSO): δ 8.42 (dd, J=7.7, 2.4 Hz, 1 H); 8.22 (d, J=2.4 Hz, 1 H); 8.03-7.96 (m, 1 H); 7.96-7.89 (m, 1 H); 7.71 (t, J=7.7 Hz, 1 H); 7.40 (d, J=8.4 Hz, 2 H); 6.96 (d, J=8.4 Hz, 2 H); 6.42 (d, J=7.7 Hz, 1 H); 5.03 (s, 2 H); 3.76 (s, 3 H); 264.1; MS (M+H)+ 387.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09024032B2 |
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| 出典データセット | uspto-grants-2015_05 |
|---|
| ORD ID | ord-36a0d579de1d45d8b3a8e11b67ffe4c4 |
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| 出典メモ | uspto-grants-2015_05 |
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