Dichloromethane → HCID 86676747, compound

Participants

Reaction Steps

A solution of N-(4-((4-nitronaphthalen-1-yl)oxy)pyridin-2-yl)morpholine-4-carboxamide (900 mg, 2.3 mmol) in a mixture of MeOH (140 mL), DCM (140 mL) and AcOH (4 drops) was subjected to hydrogenation by passage through a Thales H-cube (1.0 mL min−1, 25° C., 55 mm, 10% Pt—C Cat-Cart, full hydrogen mode). The reaction mixture was evaporated in vacuo and the residue was partitioned between DCM (50 mL) and saturated aq. NaHCO3 (20 mL). The organic phase was separated and was washed with brine (20 mL), and then dried and evaporated in vacuo to afford the title compound, Intermediate D5, as a brown solid (0.78 g, 90%); Rt 3.65 min (Method 1 basic); m/z 365 (M+H)+ (ES+).

Provenance & Evidence