Trifluoroacetic acid → HCID 67450852, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (4-(tert-butoxycarbonyl)aminonaphthalen-1-yl)(2-(tert-butoxycarbonyl)amino pyridin-4-yl)methanone (378 mg, 0.815 mmol) in DCM (20 mL) under N2 at 0° C. was added TFA (4.0 mL, 50 mmol). After 30 min at 0° C. the reaction mixture was warmed to RT for 4.5 hr and was then evaporated in vacuo. The residue was subjected to purification by SCX capture and release to afford the title compound, Intermediate G1, as a yellow solid (200 mg, 93%); Rt 1.01 min (Method 2); m/z 264 (M+H)+ (ES+).

Provenance & Evidence