Trifluoroacetic acid → HCID 67449901, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (4-(tert-butoxycarbonyl)aminonaphthalen-1-yl)(2-(tert-butoxycarbonyl)amino pyridin-4-yl)methane (270 mg, 0.60 mmol) in dry DCM (6.0 mL) under N2 at 0° C. was added TFA (2.0 mL, 25 mmol). The reaction was maintained at 0° C. for a further 20 min and was then warmed to RT for 4 hr. The mixture was evaporated in vacuo and the residue was subjected to SCX capture and release to afford the title compound, Intermediate H1, (150 mg, 100%); Rt 0.79 min (Method 2); m/z 250 (M+H)+ (ES+).

Provenance & Evidence