1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 86681609, compound

Participants

Reaction Steps

1-Ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC HCl) (59 mg, 0.309 mmol) was added to a solution of compounds (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-hydroxyethyl)pyridine 1-oxide (100 mg, 0.238 mmol), 2-(2,3-dioxo-3,4-dihydroquinoxalin-1(2H)-yl)acetic acid (63 mg, 0.286 mmol) and 4-dimethylaminopyridine (6 mg, 0.048 mmol) in CH2Cl2 (1 mL) at room temperature under nitrogen atmosphere. The mixture was stirred at room temperature overnight. The mixture was then diluted with CH2Cl2 (5 mL) and washed with NaHCO3 saturated solution (5 mL), HCL 0.1 N (5 mL) and brine (5 ml). The organic phase was dried over Na2SO4 and the solvent was evaporated, to yield 70 mg of the title compound (80% yield). MS/ESI+ 621.09 [MH]+

Provenance & Evidence