3-Hydroxyphthalic anhydride → HCID 86681619, compound

Participants

Reaction Steps

4-Hydroxyisobenzofuran-1,3-dione (600 mg, 3.66 mmol) and methyl 2-aminoacetate hydrochloride (505 mg, 4.02 mmol) were finely dispersed on Montmorillonite K10 (powder, Sigma-Aldrich) (1.2 g) and the solid mixture was reacted under microwave irradiation at 150° C. for 30 minutes. Montmorillonite was washed with MeOH and the solvent was evaporated under vacuum. The crude was purified by preparative HPLC (Method 1) recovering the title compound (160 mg, 0.680 mmol, 19% yield). MS/ESI+ 236.1 [MH]+.

Provenance & Evidence