Hydrochloric Acid → HCID 21815095, compound

Participants

Reaction Steps

To a solution of methyl 2-(4-methoxy-1,3-dioxoisoindolin-2-yl)acetate (130 mg, 0.522 mmol) in dioxane (15 ml) a 12 N aqueous solution of HCl (15 ml) was added and the mixture was reacted overnight at room temperature. The organic layer was evaporated and the desired compound was extracted with EtOAc (2×20 ml) obtaining the title compound that was used in the next step without further purification (57 mg, 0.242 mmol, 47% yield). MS/ESI+ 236.1 [MH]+.

Provenance & Evidence