Potassium Carbonate → HCID 43152087, compound

Participants

Reaction Steps

To a solution of 5-nitro-1H-indole (1 g, 6.17 mmol) in DMF (15 ml), K2CO3 (1.023 g, 7.40 mmol) and methyl 2-bromoacetate (0.686 ml, 7.40 mmol) were added, and the mixture was reacted under MW irradiation for 1 hour at 100° C. The insoluble inorganic salts were filtered off, the solvent was removed and the resulting crude was purified by flash chromatography on silica gel column (petroleum ether:ethyl acetate=8:2) to afford methyl 2-(5-nitro-1H-indol-1-yl)acetate (830 mg, 3.54 mmol, 58% yield). MS/ESI+ 234.2[MH]+.

Provenance & Evidence