Lithium Hydroxide → HCID 89518052, compound

Participants

Reaction Steps

To a solution of methyl 2-(5-(N-(tert-butoxycarbonyl)methylsulfonamido)-1H-indol-1-yl)acetate (520 mg, 1.360 mmol) in a 1:1 mixture of THF and water (20 ml), lithium hydroxide (326 mg, 13.60 mmol) was added, and the mixture was reacted for 2 hours at room temperature. The organic layer was evaporated and 1N HCl was added to the reaction mixture (pH 5); the resulting solid was filtered off affording 2-(5-(N-(tert-butoxycarbonyl)methylsulfonamido)-1H-indol-1-yl)acetic acid that was used in the next step without any additional purification (450 mg, 1.221 mmol, 90% yield). MS/ESI+ 369.2 [MH]+.

Provenance & Evidence