Hydrochloric Acid → HCID 45599134, compound

Participants

Reaction Steps

Methyl 2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)acetate (2.5 g, 9.42 mmol) was dissolved in dioxane (20 ml), and aqueous 12M HCl (6 ml, 72.0 mmol) was added. The mixture was stirred under reflux for 8 hours, then the volatiles were removed under vacuum and the resulting solid was suspended in CH3CN and recovered by filtration affording the title compound (2.2 g, 7.65 mmol, 81% yield). MS/ESI+ 252.1 [MH]+.

Provenance & Evidence