反应详情

To a solution of methyl 2-(5-amino-2-oxoindolin-1-yl)acetate (0.120 g, 0.545 mmol) in pyridine (8 ml) cooled to 0° C., methanesulfonyl chloride (0.047 ml, 0.599 mmol) was added, and the mixture was allowed to warm to room temperature and stirred for 1.5 hours. The solvent was removed and the crude was portioned between DCM and 1N HCl. The organic phase was dried over sodium sulfate, and the solvent was removed. The crude was purified by filtration on silica gel cartridge (DCM:MeOH from 99:1 to 97:3) affording methyl 2-(5-(methylsulfonamido)-2-oxoindolin-1-yl)acetate (0.133 g, 0.446 mmol, 82% yield). MS/ESI+ 298.9 [MH]+.

1. customThe solvent was removed
2. dry with materialThe organic phase was dried over sodium sulfate
3. customthe solvent was removed
4. filtrationThe crude was purified by filtration on silica gel cartridge (DCM:MeOH from 99:1 to 97:3)